sample material Search Results


gabapentin  (Chem Impex International)
95
Chem Impex International gabapentin
AIE-induced reduction of astrocyte-synapse proximity in hippocampal area CA1 is reversed by <t>gabapentin.</t> (A) Left to right: Raw z-series astrocytes (green) and synaptic puncta (red), rendered astrocytes (purple), and points of colocalization of the astrocyte and synaptic maker (white), from control animals that received AIW, those exposed to AIE, and AIE animals that received gabapentin in adulthood (AIE + gabapentin). Scale bars: 15 μm. (B) Left Column: Astrocytes (green) and synaptic puncta (red) from each of the treatment groups described under A. Inset boxes represent regions for expanded magnification. Scale bars: 15 μm. Right column: Expanded magnification of areas inset in left column. Yellow asterisks indicate identified points of astrocyte-synaptic colocalization. Scale bars: 15 μm. (C) Mean (± SEM) ratio of astrocyte surface area (SA) to volume (V) was unchanged by AIE or Gabapentin treatment. (D) Mean (± SEM) percent of colocalization of astrocyte viral labeling and synaptic puncta was reduced in hippocampal area CA1 in adulthood following AIE ( P < 0.05, vs . AIW), and this decrease was reversed by treatment with gabapentin ( P < 0.05, vs . AIE and P > 0.05, vs . AIW + gabapentin). The number of animals used for each treatment group was: AIW – n = 6, AIE – n = 6, AIW + gabapentin – n = 8, AIE + gabapentin – n = 7. An average of five cells per animal were included in the mixed linear modeling analysis. AIE: Adolescent intermittent ethanol; AIW: adolescent intermittent water.
Gabapentin, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/gabapentin/product/Chem Impex International
Average 95 stars, based on 1 article reviews
gabapentin - by Bioz Stars, 2026-05
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weight nucleobond kit  (MACHEREY NAGEL)
96
MACHEREY NAGEL weight nucleobond kit
AIE-induced reduction of astrocyte-synapse proximity in hippocampal area CA1 is reversed by <t>gabapentin.</t> (A) Left to right: Raw z-series astrocytes (green) and synaptic puncta (red), rendered astrocytes (purple), and points of colocalization of the astrocyte and synaptic maker (white), from control animals that received AIW, those exposed to AIE, and AIE animals that received gabapentin in adulthood (AIE + gabapentin). Scale bars: 15 μm. (B) Left Column: Astrocytes (green) and synaptic puncta (red) from each of the treatment groups described under A. Inset boxes represent regions for expanded magnification. Scale bars: 15 μm. Right column: Expanded magnification of areas inset in left column. Yellow asterisks indicate identified points of astrocyte-synaptic colocalization. Scale bars: 15 μm. (C) Mean (± SEM) ratio of astrocyte surface area (SA) to volume (V) was unchanged by AIE or Gabapentin treatment. (D) Mean (± SEM) percent of colocalization of astrocyte viral labeling and synaptic puncta was reduced in hippocampal area CA1 in adulthood following AIE ( P < 0.05, vs . AIW), and this decrease was reversed by treatment with gabapentin ( P < 0.05, vs . AIE and P > 0.05, vs . AIW + gabapentin). The number of animals used for each treatment group was: AIW – n = 6, AIE – n = 6, AIW + gabapentin – n = 8, AIE + gabapentin – n = 7. An average of five cells per animal were included in the mixed linear modeling analysis. AIE: Adolescent intermittent ethanol; AIW: adolescent intermittent water.
Weight Nucleobond Kit, supplied by MACHEREY NAGEL, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 96 stars, based on 1 article reviews
weight nucleobond kit - by Bioz Stars, 2026-05
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recombinant anti-sars-cov-2 antibodies  (Diaserve Laboratories)
90
Diaserve Laboratories recombinant anti-sars-cov-2 antibodies
AIE-induced reduction of astrocyte-synapse proximity in hippocampal area CA1 is reversed by <t>gabapentin.</t> (A) Left to right: Raw z-series astrocytes (green) and synaptic puncta (red), rendered astrocytes (purple), and points of colocalization of the astrocyte and synaptic maker (white), from control animals that received AIW, those exposed to AIE, and AIE animals that received gabapentin in adulthood (AIE + gabapentin). Scale bars: 15 μm. (B) Left Column: Astrocytes (green) and synaptic puncta (red) from each of the treatment groups described under A. Inset boxes represent regions for expanded magnification. Scale bars: 15 μm. Right column: Expanded magnification of areas inset in left column. Yellow asterisks indicate identified points of astrocyte-synaptic colocalization. Scale bars: 15 μm. (C) Mean (± SEM) ratio of astrocyte surface area (SA) to volume (V) was unchanged by AIE or Gabapentin treatment. (D) Mean (± SEM) percent of colocalization of astrocyte viral labeling and synaptic puncta was reduced in hippocampal area CA1 in adulthood following AIE ( P < 0.05, vs . AIW), and this decrease was reversed by treatment with gabapentin ( P < 0.05, vs . AIE and P > 0.05, vs . AIW + gabapentin). The number of animals used for each treatment group was: AIW – n = 6, AIE – n = 6, AIW + gabapentin – n = 8, AIE + gabapentin – n = 7. An average of five cells per animal were included in the mixed linear modeling analysis. AIE: Adolescent intermittent ethanol; AIW: adolescent intermittent water.
Recombinant Anti Sars Cov 2 Antibodies, supplied by Diaserve Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/recombinant anti-sars-cov-2 antibodies/product/Diaserve Laboratories
Average 90 stars, based on 1 article reviews
recombinant anti-sars-cov-2 antibodies - by Bioz Stars, 2026-05
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standardized biological material collection kit stool sample application system (sas)  (Immundiagnostik AG)
90
Immundiagnostik AG standardized biological material collection kit stool sample application system (sas)
AIE-induced reduction of astrocyte-synapse proximity in hippocampal area CA1 is reversed by <t>gabapentin.</t> (A) Left to right: Raw z-series astrocytes (green) and synaptic puncta (red), rendered astrocytes (purple), and points of colocalization of the astrocyte and synaptic maker (white), from control animals that received AIW, those exposed to AIE, and AIE animals that received gabapentin in adulthood (AIE + gabapentin). Scale bars: 15 μm. (B) Left Column: Astrocytes (green) and synaptic puncta (red) from each of the treatment groups described under A. Inset boxes represent regions for expanded magnification. Scale bars: 15 μm. Right column: Expanded magnification of areas inset in left column. Yellow asterisks indicate identified points of astrocyte-synaptic colocalization. Scale bars: 15 μm. (C) Mean (± SEM) ratio of astrocyte surface area (SA) to volume (V) was unchanged by AIE or Gabapentin treatment. (D) Mean (± SEM) percent of colocalization of astrocyte viral labeling and synaptic puncta was reduced in hippocampal area CA1 in adulthood following AIE ( P < 0.05, vs . AIW), and this decrease was reversed by treatment with gabapentin ( P < 0.05, vs . AIE and P > 0.05, vs . AIW + gabapentin). The number of animals used for each treatment group was: AIW – n = 6, AIE – n = 6, AIW + gabapentin – n = 8, AIE + gabapentin – n = 7. An average of five cells per animal were included in the mixed linear modeling analysis. AIE: Adolescent intermittent ethanol; AIW: adolescent intermittent water.
Standardized Biological Material Collection Kit Stool Sample Application System (Sas), supplied by Immundiagnostik AG, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/standardized biological material collection kit stool sample application system (sas)/product/Immundiagnostik AG
Average 90 stars, based on 1 article reviews
standardized biological material collection kit stool sample application system (sas) - by Bioz Stars, 2026-05
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gdl sample material  (SGL Technologies GmbH)
90
SGL Technologies GmbH gdl sample material
AIE-induced reduction of astrocyte-synapse proximity in hippocampal area CA1 is reversed by <t>gabapentin.</t> (A) Left to right: Raw z-series astrocytes (green) and synaptic puncta (red), rendered astrocytes (purple), and points of colocalization of the astrocyte and synaptic maker (white), from control animals that received AIW, those exposed to AIE, and AIE animals that received gabapentin in adulthood (AIE + gabapentin). Scale bars: 15 μm. (B) Left Column: Astrocytes (green) and synaptic puncta (red) from each of the treatment groups described under A. Inset boxes represent regions for expanded magnification. Scale bars: 15 μm. Right column: Expanded magnification of areas inset in left column. Yellow asterisks indicate identified points of astrocyte-synaptic colocalization. Scale bars: 15 μm. (C) Mean (± SEM) ratio of astrocyte surface area (SA) to volume (V) was unchanged by AIE or Gabapentin treatment. (D) Mean (± SEM) percent of colocalization of astrocyte viral labeling and synaptic puncta was reduced in hippocampal area CA1 in adulthood following AIE ( P < 0.05, vs . AIW), and this decrease was reversed by treatment with gabapentin ( P < 0.05, vs . AIE and P > 0.05, vs . AIW + gabapentin). The number of animals used for each treatment group was: AIW – n = 6, AIE – n = 6, AIW + gabapentin – n = 8, AIE + gabapentin – n = 7. An average of five cells per animal were included in the mixed linear modeling analysis. AIE: Adolescent intermittent ethanol; AIW: adolescent intermittent water.
Gdl Sample Material, supplied by SGL Technologies GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/gdl sample material/product/SGL Technologies GmbH
Average 90 stars, based on 1 article reviews
gdl sample material - by Bioz Stars, 2026-05
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cereal-based animal feed sample (product code fcma2-afe2qc; material t04425qc)  (Fera Science Ltd)
90
Fera Science Ltd cereal-based animal feed sample (product code fcma2-afe2qc; material t04425qc)
AIE-induced reduction of astrocyte-synapse proximity in hippocampal area CA1 is reversed by <t>gabapentin.</t> (A) Left to right: Raw z-series astrocytes (green) and synaptic puncta (red), rendered astrocytes (purple), and points of colocalization of the astrocyte and synaptic maker (white), from control animals that received AIW, those exposed to AIE, and AIE animals that received gabapentin in adulthood (AIE + gabapentin). Scale bars: 15 μm. (B) Left Column: Astrocytes (green) and synaptic puncta (red) from each of the treatment groups described under A. Inset boxes represent regions for expanded magnification. Scale bars: 15 μm. Right column: Expanded magnification of areas inset in left column. Yellow asterisks indicate identified points of astrocyte-synaptic colocalization. Scale bars: 15 μm. (C) Mean (± SEM) ratio of astrocyte surface area (SA) to volume (V) was unchanged by AIE or Gabapentin treatment. (D) Mean (± SEM) percent of colocalization of astrocyte viral labeling and synaptic puncta was reduced in hippocampal area CA1 in adulthood following AIE ( P < 0.05, vs . AIW), and this decrease was reversed by treatment with gabapentin ( P < 0.05, vs . AIE and P > 0.05, vs . AIW + gabapentin). The number of animals used for each treatment group was: AIW – n = 6, AIE – n = 6, AIW + gabapentin – n = 8, AIE + gabapentin – n = 7. An average of five cells per animal were included in the mixed linear modeling analysis. AIE: Adolescent intermittent ethanol; AIW: adolescent intermittent water.
Cereal Based Animal Feed Sample (Product Code Fcma2 Afe2qc; Material T04425qc), supplied by Fera Science Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/cereal-based animal feed sample (product code fcma2-afe2qc; material t04425qc)/product/Fera Science Ltd
Average 90 stars, based on 1 article reviews
cereal-based animal feed sample (product code fcma2-afe2qc; material t04425qc) - by Bioz Stars, 2026-05
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h-zsm-5 zeolite si/al ~ 19  (Nanjing XFNANO Materials Tech Co Ltd)
90
Nanjing XFNANO Materials Tech Co Ltd h-zsm-5 zeolite si/al ~ 19
AIE-induced reduction of astrocyte-synapse proximity in hippocampal area CA1 is reversed by <t>gabapentin.</t> (A) Left to right: Raw z-series astrocytes (green) and synaptic puncta (red), rendered astrocytes (purple), and points of colocalization of the astrocyte and synaptic maker (white), from control animals that received AIW, those exposed to AIE, and AIE animals that received gabapentin in adulthood (AIE + gabapentin). Scale bars: 15 μm. (B) Left Column: Astrocytes (green) and synaptic puncta (red) from each of the treatment groups described under A. Inset boxes represent regions for expanded magnification. Scale bars: 15 μm. Right column: Expanded magnification of areas inset in left column. Yellow asterisks indicate identified points of astrocyte-synaptic colocalization. Scale bars: 15 μm. (C) Mean (± SEM) ratio of astrocyte surface area (SA) to volume (V) was unchanged by AIE or Gabapentin treatment. (D) Mean (± SEM) percent of colocalization of astrocyte viral labeling and synaptic puncta was reduced in hippocampal area CA1 in adulthood following AIE ( P < 0.05, vs . AIW), and this decrease was reversed by treatment with gabapentin ( P < 0.05, vs . AIE and P > 0.05, vs . AIW + gabapentin). The number of animals used for each treatment group was: AIW – n = 6, AIE – n = 6, AIW + gabapentin – n = 8, AIE + gabapentin – n = 7. An average of five cells per animal were included in the mixed linear modeling analysis. AIE: Adolescent intermittent ethanol; AIW: adolescent intermittent water.
H Zsm 5 Zeolite Si/Al ~ 19, supplied by Nanjing XFNANO Materials Tech Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/h-zsm-5 zeolite si/al ~ 19/product/Nanjing XFNANO Materials Tech Co Ltd
Average 90 stars, based on 1 article reviews
h-zsm-5 zeolite si/al ~ 19 - by Bioz Stars, 2026-05
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peanut seed samples henan yuhua 9326  (Henan Yuhua New Material Co Ltd)
90
Henan Yuhua New Material Co Ltd peanut seed samples henan yuhua 9326
AIE-induced reduction of astrocyte-synapse proximity in hippocampal area CA1 is reversed by <t>gabapentin.</t> (A) Left to right: Raw z-series astrocytes (green) and synaptic puncta (red), rendered astrocytes (purple), and points of colocalization of the astrocyte and synaptic maker (white), from control animals that received AIW, those exposed to AIE, and AIE animals that received gabapentin in adulthood (AIE + gabapentin). Scale bars: 15 μm. (B) Left Column: Astrocytes (green) and synaptic puncta (red) from each of the treatment groups described under A. Inset boxes represent regions for expanded magnification. Scale bars: 15 μm. Right column: Expanded magnification of areas inset in left column. Yellow asterisks indicate identified points of astrocyte-synaptic colocalization. Scale bars: 15 μm. (C) Mean (± SEM) ratio of astrocyte surface area (SA) to volume (V) was unchanged by AIE or Gabapentin treatment. (D) Mean (± SEM) percent of colocalization of astrocyte viral labeling and synaptic puncta was reduced in hippocampal area CA1 in adulthood following AIE ( P < 0.05, vs . AIW), and this decrease was reversed by treatment with gabapentin ( P < 0.05, vs . AIE and P > 0.05, vs . AIW + gabapentin). The number of animals used for each treatment group was: AIW – n = 6, AIE – n = 6, AIW + gabapentin – n = 8, AIE + gabapentin – n = 7. An average of five cells per animal were included in the mixed linear modeling analysis. AIE: Adolescent intermittent ethanol; AIW: adolescent intermittent water.
Peanut Seed Samples Henan Yuhua 9326, supplied by Henan Yuhua New Material Co Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/peanut seed samples henan yuhua 9326/product/Henan Yuhua New Material Co Ltd
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tio2 nanoparticles  (Amorphous Materials Inc)
90
Amorphous Materials Inc tio2 nanoparticles
AIE-induced reduction of astrocyte-synapse proximity in hippocampal area CA1 is reversed by <t>gabapentin.</t> (A) Left to right: Raw z-series astrocytes (green) and synaptic puncta (red), rendered astrocytes (purple), and points of colocalization of the astrocyte and synaptic maker (white), from control animals that received AIW, those exposed to AIE, and AIE animals that received gabapentin in adulthood (AIE + gabapentin). Scale bars: 15 μm. (B) Left Column: Astrocytes (green) and synaptic puncta (red) from each of the treatment groups described under A. Inset boxes represent regions for expanded magnification. Scale bars: 15 μm. Right column: Expanded magnification of areas inset in left column. Yellow asterisks indicate identified points of astrocyte-synaptic colocalization. Scale bars: 15 μm. (C) Mean (± SEM) ratio of astrocyte surface area (SA) to volume (V) was unchanged by AIE or Gabapentin treatment. (D) Mean (± SEM) percent of colocalization of astrocyte viral labeling and synaptic puncta was reduced in hippocampal area CA1 in adulthood following AIE ( P < 0.05, vs . AIW), and this decrease was reversed by treatment with gabapentin ( P < 0.05, vs . AIE and P > 0.05, vs . AIW + gabapentin). The number of animals used for each treatment group was: AIW – n = 6, AIE – n = 6, AIW + gabapentin – n = 8, AIE + gabapentin – n = 7. An average of five cells per animal were included in the mixed linear modeling analysis. AIE: Adolescent intermittent ethanol; AIW: adolescent intermittent water.
Tio2 Nanoparticles, supplied by Amorphous Materials Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/tio2 nanoparticles/product/Amorphous Materials Inc
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plant material and dna samples provided by kws saat ag  (KWS Saat AG)
90
KWS Saat AG plant material and dna samples provided by kws saat ag
AIE-induced reduction of astrocyte-synapse proximity in hippocampal area CA1 is reversed by <t>gabapentin.</t> (A) Left to right: Raw z-series astrocytes (green) and synaptic puncta (red), rendered astrocytes (purple), and points of colocalization of the astrocyte and synaptic maker (white), from control animals that received AIW, those exposed to AIE, and AIE animals that received gabapentin in adulthood (AIE + gabapentin). Scale bars: 15 μm. (B) Left Column: Astrocytes (green) and synaptic puncta (red) from each of the treatment groups described under A. Inset boxes represent regions for expanded magnification. Scale bars: 15 μm. Right column: Expanded magnification of areas inset in left column. Yellow asterisks indicate identified points of astrocyte-synaptic colocalization. Scale bars: 15 μm. (C) Mean (± SEM) ratio of astrocyte surface area (SA) to volume (V) was unchanged by AIE or Gabapentin treatment. (D) Mean (± SEM) percent of colocalization of astrocyte viral labeling and synaptic puncta was reduced in hippocampal area CA1 in adulthood following AIE ( P < 0.05, vs . AIW), and this decrease was reversed by treatment with gabapentin ( P < 0.05, vs . AIE and P > 0.05, vs . AIW + gabapentin). The number of animals used for each treatment group was: AIW – n = 6, AIE – n = 6, AIW + gabapentin – n = 8, AIE + gabapentin – n = 7. An average of five cells per animal were included in the mixed linear modeling analysis. AIE: Adolescent intermittent ethanol; AIW: adolescent intermittent water.
Plant Material And Dna Samples Provided By Kws Saat Ag, supplied by KWS Saat AG, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/plant material and dna samples provided by kws saat ag/product/KWS Saat AG
Average 90 stars, based on 1 article reviews
plant material and dna samples provided by kws saat ag - by Bioz Stars, 2026-05
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samples (feed raw materials)  (Biomin GmbH)
90
Biomin GmbH samples (feed raw materials)
AIE-induced reduction of astrocyte-synapse proximity in hippocampal area CA1 is reversed by <t>gabapentin.</t> (A) Left to right: Raw z-series astrocytes (green) and synaptic puncta (red), rendered astrocytes (purple), and points of colocalization of the astrocyte and synaptic maker (white), from control animals that received AIW, those exposed to AIE, and AIE animals that received gabapentin in adulthood (AIE + gabapentin). Scale bars: 15 μm. (B) Left Column: Astrocytes (green) and synaptic puncta (red) from each of the treatment groups described under A. Inset boxes represent regions for expanded magnification. Scale bars: 15 μm. Right column: Expanded magnification of areas inset in left column. Yellow asterisks indicate identified points of astrocyte-synaptic colocalization. Scale bars: 15 μm. (C) Mean (± SEM) ratio of astrocyte surface area (SA) to volume (V) was unchanged by AIE or Gabapentin treatment. (D) Mean (± SEM) percent of colocalization of astrocyte viral labeling and synaptic puncta was reduced in hippocampal area CA1 in adulthood following AIE ( P < 0.05, vs . AIW), and this decrease was reversed by treatment with gabapentin ( P < 0.05, vs . AIE and P > 0.05, vs . AIW + gabapentin). The number of animals used for each treatment group was: AIW – n = 6, AIE – n = 6, AIW + gabapentin – n = 8, AIE + gabapentin – n = 7. An average of five cells per animal were included in the mixed linear modeling analysis. AIE: Adolescent intermittent ethanol; AIW: adolescent intermittent water.
Samples (Feed Raw Materials), supplied by Biomin GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/samples (feed raw materials)/product/Biomin GmbH
Average 90 stars, based on 1 article reviews
samples (feed raw materials) - by Bioz Stars, 2026-05
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samples of gm plant materials  (Joint Research Center)
90
Joint Research Center samples of gm plant materials
AIE-induced reduction of astrocyte-synapse proximity in hippocampal area CA1 is reversed by <t>gabapentin.</t> (A) Left to right: Raw z-series astrocytes (green) and synaptic puncta (red), rendered astrocytes (purple), and points of colocalization of the astrocyte and synaptic maker (white), from control animals that received AIW, those exposed to AIE, and AIE animals that received gabapentin in adulthood (AIE + gabapentin). Scale bars: 15 μm. (B) Left Column: Astrocytes (green) and synaptic puncta (red) from each of the treatment groups described under A. Inset boxes represent regions for expanded magnification. Scale bars: 15 μm. Right column: Expanded magnification of areas inset in left column. Yellow asterisks indicate identified points of astrocyte-synaptic colocalization. Scale bars: 15 μm. (C) Mean (± SEM) ratio of astrocyte surface area (SA) to volume (V) was unchanged by AIE or Gabapentin treatment. (D) Mean (± SEM) percent of colocalization of astrocyte viral labeling and synaptic puncta was reduced in hippocampal area CA1 in adulthood following AIE ( P < 0.05, vs . AIW), and this decrease was reversed by treatment with gabapentin ( P < 0.05, vs . AIE and P > 0.05, vs . AIW + gabapentin). The number of animals used for each treatment group was: AIW – n = 6, AIE – n = 6, AIW + gabapentin – n = 8, AIE + gabapentin – n = 7. An average of five cells per animal were included in the mixed linear modeling analysis. AIE: Adolescent intermittent ethanol; AIW: adolescent intermittent water.
Samples Of Gm Plant Materials, supplied by Joint Research Center, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/samples of gm plant materials/product/Joint Research Center
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Image Search Results


AIE-induced reduction of astrocyte-synapse proximity in hippocampal area CA1 is reversed by gabapentin. (A) Left to right: Raw z-series astrocytes (green) and synaptic puncta (red), rendered astrocytes (purple), and points of colocalization of the astrocyte and synaptic maker (white), from control animals that received AIW, those exposed to AIE, and AIE animals that received gabapentin in adulthood (AIE + gabapentin). Scale bars: 15 μm. (B) Left Column: Astrocytes (green) and synaptic puncta (red) from each of the treatment groups described under A. Inset boxes represent regions for expanded magnification. Scale bars: 15 μm. Right column: Expanded magnification of areas inset in left column. Yellow asterisks indicate identified points of astrocyte-synaptic colocalization. Scale bars: 15 μm. (C) Mean (± SEM) ratio of astrocyte surface area (SA) to volume (V) was unchanged by AIE or Gabapentin treatment. (D) Mean (± SEM) percent of colocalization of astrocyte viral labeling and synaptic puncta was reduced in hippocampal area CA1 in adulthood following AIE ( P < 0.05, vs . AIW), and this decrease was reversed by treatment with gabapentin ( P < 0.05, vs . AIE and P > 0.05, vs . AIW + gabapentin). The number of animals used for each treatment group was: AIW – n = 6, AIE – n = 6, AIW + gabapentin – n = 8, AIE + gabapentin – n = 7. An average of five cells per animal were included in the mixed linear modeling analysis. AIE: Adolescent intermittent ethanol; AIW: adolescent intermittent water.

Journal: Neural Regeneration Research

Article Title: Enduring alterations in hippocampal astrocyte-synaptic proximity following adolescent alcohol exposure: reversal by gabapentin

doi: 10.4103/1673-5374.274339

Figure Lengend Snippet: AIE-induced reduction of astrocyte-synapse proximity in hippocampal area CA1 is reversed by gabapentin. (A) Left to right: Raw z-series astrocytes (green) and synaptic puncta (red), rendered astrocytes (purple), and points of colocalization of the astrocyte and synaptic maker (white), from control animals that received AIW, those exposed to AIE, and AIE animals that received gabapentin in adulthood (AIE + gabapentin). Scale bars: 15 μm. (B) Left Column: Astrocytes (green) and synaptic puncta (red) from each of the treatment groups described under A. Inset boxes represent regions for expanded magnification. Scale bars: 15 μm. Right column: Expanded magnification of areas inset in left column. Yellow asterisks indicate identified points of astrocyte-synaptic colocalization. Scale bars: 15 μm. (C) Mean (± SEM) ratio of astrocyte surface area (SA) to volume (V) was unchanged by AIE or Gabapentin treatment. (D) Mean (± SEM) percent of colocalization of astrocyte viral labeling and synaptic puncta was reduced in hippocampal area CA1 in adulthood following AIE ( P < 0.05, vs . AIW), and this decrease was reversed by treatment with gabapentin ( P < 0.05, vs . AIE and P > 0.05, vs . AIW + gabapentin). The number of animals used for each treatment group was: AIW – n = 6, AIE – n = 6, AIW + gabapentin – n = 8, AIE + gabapentin – n = 7. An average of five cells per animal were included in the mixed linear modeling analysis. AIE: Adolescent intermittent ethanol; AIW: adolescent intermittent water.

Article Snippet: Approximately 2 weeks after virus surgery (described below), gabapentin (100 mg/kg in sterile 0.9% NaCl, i.p.; Chem-Impex International, Inc., Wood Dale, IL, USA) or isovolumetric saline injections were initiated.

Techniques: Labeling